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Infectious foot-and-mouth disease virus derived from a cloned full-length cDNA

1 Jun 1990

Abstract excerpt

A full-length cDNA plasmid of foot-and-mouth disease virus has been constructed. RNA synthesized in vitro by means of a bacteriophage SP6 promoter inserted in front of the cDNA led to the production of infectious particles upon transfection of BHK-21 cells. These particles were also found to be highly infectious for primary bovine kidney cells as well as for baby mice. The difficulty in cloning the foot-and-mouth...

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Identifiers

PMID: 2159523
DOI: 10.1128/jvi.64.6.2467-2473.1990

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