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Article

Genetically engineered foot-and-mouth disease viruses with poly(C) tracts of two nucleotides are virulent in mice

1 Sept 1993

Abstract excerpt

To determine the role of the poly(C) tract found at the 5' end of the genome of foot-and-mouth disease virus, synthetic RNAs (in vitro transcripts) with poly(C) tracts of different lengths have been produced and evaluated. RNAs with poly(C) tracts of 35, 25, 16, 6, or 2 residues displayed similar specific infectivities in baby hamster kidney (BHK) cells. Viruses recovered from cells transfected with in vitro...

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Identifiers

PMID: 8394441
DOI: 10.1128/jvi.67.9.5139-5145.1993

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