When is the absence of evidence, evidence of absence? Use of equivalence-based analyses in genetic epidemiology and a conclusion for the KIF1B rs10492972*C allelic association in multiple sclerosis.

Abstract excerpt

Statistical equivalence methods have been in development since the late 1980s in order to provide an appropriate statistical methodology to address nondifferences in biological experiments. This is analogous to genetic association studies in which a polymorphism "is not associated" with a trait. We applied the equivalence method to genetic data to confirm that an association between the KIF1B (kinesin family...

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