Article
A tick-borne encephalitis virus vaccine based on the European prototype strain induces broadly reactive cross-neutralizing antibodies in humans.
The Journal of infectious diseases - 1 Jun 2011
Orlinger Klaus K, Hofmeister Yvonne, Fritz Richard, Holzer Georg W, Falkner Falko G, Unger Bernd, Loew-Baselli Alexandra, Poellabauer Eva-Maria, Ehrlich Hartmut J, Barrett P Noel, Kreil Thomas R
Abstract excerpt
After vaccination of humans with tick-borne encephalitis virus (TBEV) vaccine, the extent of cross-neutralization between viruses of the European, Far Eastern, and Siberian subtypes of TBEV and Omsk hemorrhagic fever virus (OHFV) was analyzed. Hybrid viruses that encode the TBEV surface proteins for representative viruses within all subtypes, and OHFV, were constructed using the West Nile virus (WNV) backbone as...
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