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Article

Akt/PKB isoforms expression in the human lumbar herniated disc: correlation with clinical and MRI findings.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society - 1 Oct 2011

Pasku Dritan, Soufla Giannoula, Katonis Pavlos, Tsarouhas Alexandros, Vakis Antonis, Spandidos Demetrios A

Abstract excerpt

Intervertebral disc (IVD) degeneration suggests a complex process influenced by genetics, lifestyle and biomechanics, which accounts for the development of low back pain (LBP) and lumbar radiculopathy, a major cause of musculoskeletal disability in humans. The family of Akt/PKB kinases is a principal mediator in the signal transduction pathways, which contribute to transcriptional regulation, cell growth,...

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Topics

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Share to Gene Expression Regulation, Enzymologic
Share to Intervertebral Disc Displacement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isoenzymes

Share to Lumbar Vertebrae

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Share to Proto-Oncogene Proteins c-akt

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Source

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Identifiers

PMID: 21590431
DOI: 10.1007/s00586-011-1841-3
PMCID: PMC3175883

Genes

AKT2
IVD
AKT1
AKT3
LBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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