Article
Unstable hemoglobin Rush [beta 101(G3) Glu>Gln, HBB:c.304G>C] in a Brazilian family with moderate hemolytic anemia.
Annals of hematology - 1 Jul 2012
Silva Marcilene Rezende, Sendin Shimene Mascarenhas, Velloso-Rodrigues Cibele, Belisário André Rolim, D'Ávila Terezinha Santos, Lyra Liege Ribeiro, Viana Marcos Borato
Abstract excerpt
Hemoglobin Rush is an unstable variant generated by a mutation of the β-globin gene which causes amino acid replacement Glu>Gln in the central cavity of hemoglobin (G3). Many members of a Brazilian family of Italian descent have hemoglobin Rush. This is the second report in world literature. Clinical and laboratory features were retrieved and gene mutation was characterized. Hemoglobin electrophoresis, gene...
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