Article
[The role of vascular endothelial growth factor in angiogenesis and diabetic retinopathy].
Arquivos brasileiros de endocrinologia e metabologia - 1 Mar 2011
Valiatti Fabiana Borba, Crispim Daisy, Benfica Camila, Valiatti Bruna Borba, Kramer Caroline K, Canani Luís Henrique
Abstract excerpt
Diabetic retinopathy (DR), a DM microvascular complication, is the leading cause of blindness. Angiogenic factors such as vascular endothelial growth factor (VEGF) are involved in the pathogenesis of DR. VEGF-A is a potent, multifunctional cytokine that acts through the receptors VEGFR-1 and VEGFR-2 expressed in the vascular endothelium and causing increased vascular permeability and neovascularization...
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