Article
Association between CST3 rs2424577 polymorphism and corpulence related phenotypes during lifetime in populations of European ancestry.
Obesity facts - 1 Jan 2011
Hooton Henri, Dubern Beatrice, Henegar Corneliu, Paternoster Lavinia, Nohr Ellen A, Alili Rohia, Rousseau Francis, Pelloux Veronique, Galan Pilar, Hercberg Serge, Arner Peter, Sørensen Thorkild I A, Clément Karine
Abstract excerpt
OBJECTIVE: Cystatin C, a protein coded by CST3 gene, is implicated in adipose tissue biology. Our hypothesis is that common variants in CST3 gene could play a role in the development of corpulence during lifetime. METHODS: Two tag SNPs were selected to capture all SNPs in the CST3 region. We first investigated the association of the two tag SNPs individually and combined into haplotypes with corpulence related...
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