Article
A genetic variation in the 5' flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity.
Diabetologia - 1 Feb 2000
Otabe S, Clement K, Dina C, Pelloux V, Guy-Grand B, Froguel P, Vasseur F
Abstract excerpt
AIMS/HYPOTHESIS: In obese French Caucasian subjects we previously described a silent UCP3 Tyr99Tyr mutation, associated with body mass index. We hypothesised that an unknown polymorphism in the vicinity of the gene could contribute to obesity. METHODS: Morbidly obese subjects were screened for mutations in 1 kb upstream from the UCP3 gene. Association studies were done between a variant and obesity in 401...
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