Article
Common variants in a novel gene, FONG on chromosome 2q33.1 confer risk of osteoporosis in Japanese.
PloS one - 6 May 2011
Kou Ikuyo, Takahashi Atsushi, Urano Tomohiko, Fukui Naoshi, Ito Hideki, Ozaki Kouichi, Tanaka Toshihiro, Hosoi Takayuki, Shiraki Masataka, Inoue Satoshi, Nakamura Yusuke, Kamatani Naoyuki, Kubo Michiaki, Mori Seijiro, Ikegawa Shiro
Abstract excerpt
Osteoporosis is a common disease characterized by low bone mass, decreased bone quality and increased predisposition to fracture. Genetic factors have been implicated in its etiology; however, the specific genes related to susceptibility to osteoporosis are not entirely known. To detect susceptibility genes for osteoporosis, we conducted a genome-wide association study in Japanese using ∼270,000 SNPs in 1,747...
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