Article
DNA stress and strain, in silico, in vitro and in vivo.
Physical biology - 1 Jun 2011
Levens David, Benham Craig J
Abstract excerpt
A vast literature has explored the genetic interactions among the cellular components regulating gene expression in many organisms. Early on, in the absence of any biochemical definition, regulatory modules were conceived using the strict formalism of genetics to designate the modifiers of phenotype as either cis- or trans-acting depending on whether the relevant genes were embedded in the same or separate DNA...
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