Article
Effect of polymyxins on the lipopolysaccharide-defective mutants of Proteus mirabilis.
Microbios - 1 Jan 1990
Kaca W, Radziejewska-Lebrecht J, Bhat U R
Abstract excerpt
The effects of polymyxins (Pmx) B and E on smooth and rough Proteus mirabilis strains were investigated. P. mirabilis mutant R4/028 which completely lacked 4-amino-4-deoxy-L-arabinose was sensitive towards both polymyxins, and the other P. mirabilis strains investigated were resistant. Lipopolysaccharide (LPS) from Pmx-sensitive R4/028 strain, binds 50% more Pmx B than LPS derived from resistant P. mirabilis...
Topics
- Chloramphenicol
- Drug Resistance, Microbial
- Ethylmaleimide
- Iodoacetamide
- Lipopolysaccharides
- Mutation
- Polymyxin B
- Polymyxins
- Proteus mirabilis
