Article
The presence of anti-LPS antibodies and human serum activity against Proteus mirabilis S/R forms in correlation with TLR4 (Thr399Ile) gene polymorphism in rheumatoid arthritis.
Clinical biochemistry - 1 Nov 2012
Arabski Michal, Fudala Rafal, Koza Anna, Wasik Slawomir, Futoma-Koloch Bozena, Bugla-Ploskonska Gabriela, Kaca Wieslaw
Abstract excerpt
OBJECTIVES: Proteus mirabilis strains are human pathogens responsible for urinary tract infections, which may also be involved in rheumatoid arthritis (RA). DESIGN AND METHODS: We determined whether the binding site of anti-LPS antibodies on the O-polysaccharide part of P. mirabilis LPS correlates with the level of TLR4 (Thr399Ile) gene polymorphism in the sera of RA patients. We investigated the deposition of...
Topics
- Adult
- Aged
- Aged, 80 and over
- Amino Acid Substitution
- Amplified Fragment Length Polymorphism Analysis
- Antibodies, Bacterial
- Arthritis, Rheumatoid
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Association Studies
- Humans