Article
Knockout of Murine Mamld1 Impairs Testicular Growth and Daily Sperm Production but Permits Normal Postnatal Androgen Production and Fertility.
International journal of molecular sciences - 19 Jun 2017
Miyado Mami, Yoshida Kaoru, Miyado Kenji, Katsumi Momori, Saito Kazuki, Nakamura Shigeru, Ogata Tsutomu, Fukami Maki
Abstract excerpt
MAMLD1 has been implicated in testicular function in both human and mouse fetuses. Although three patients with MAMLD1 mutations were reported to have hypergonadotropic hypogonadism in their teens, the functional significance of MAMLD1 in the postnatal testis remains unclear. Here, we analyzed the phenotype of Mamld1 knockout (KO) male mice at reproductive ages. The reproductive organs of KO male mice were...
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