Article
Generation of a Predictive Melphalan Resistance Index by Drug Screen of B-Cell Cancer Cell Lines
29 Apr 2011
Abstract excerpt
BACKGROUND: Recent reports indicate that in vitro drug screens combined with gene expression profiles (GEP) of cancer cell lines may generate informative signatures predicting the clinical outcome of chemotherapy. In multiple myeloma (MM) a range of new drugs have been introduced and now challenge conventional therapy including high dose melphalan. Consequently, the generation of predictive signatures for...
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