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Cis-acting mutation and duplication: History of molecular evolution in a P450 haplotype responsible for insecticide resistance in Culex quinquefasciatus.

Insect biochemistry and molecular biology - 1 Jul 2011

Itokawa Kentaro, Komagata Osamu, Kasai Shinji, Masada Masahiro, Tomita Takashi

Abstract excerpt

A cytochrome P450 gene, Cyp9m10, is more than 200-fold overexpressed in a pyrethroid resistant strain of Culex quinquefasciatus, JPal-per. The haplotype of this strain contains two copies of Cyp9m10 resulted from recent tandem duplication. In this study, we discovered and isolated a Cyp9m10 haplotype closely related to this duplicated Cyp9m10 haplotype from JHB, a strain used for the recent genome project for...

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Africa
Asia
Culex
Genome, Insect
Insect Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insecticide Resistance

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PMID: 21540111
DOI: 10.1016/j.ibmb.2011.04.002

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