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Article

POMC and TP53 genetic variability and risk of basal cell carcinoma of skin: Interaction between host and genetic factors.

Journal of dermatological science - 1 Jul 2011

Rizzato Cosmeri, Scherer Dominique, Rudnai Peter, Gurzau Eugen, Koppova Kvetoslava, Hemminki Kari, Canzian Federico, Kumar Rajiv, Campa Daniele

Abstract excerpt

BACKGROUND: Basal cell carcinoma (BCC) of the skin is the most common neoplasm among the Caucasian population of the western world. Ultraviolet (UV) radiation-induced p53 activation promotes cutaneous pigmentation by increasing transcriptional activity of pro-opiomelanocortin (POMC) in the skin. Induction of POMC/α-melanocyte-stimulating hormone (α-MSH) activates the melanocortin 1 receptor (MC1R), resulting in...

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Identifiers

PMID: 21536413
DOI: 10.1016/j.jdermsci.2011.03.006

Genes

POMC

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