Article
Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice.
Nature genetics - 1 Jun 2011
Nair K Saidas, Hmani-Aifa Mounira, Ali Zain, Kearney Alison L, Ben Salem Salma, Macalinao Danilo G, Cosma Ioan M, Bouassida Walid, Hakim Bochra, Benzina Zeineb, Soto Ileana, Söderkvist Peter, Howell Gareth R, Smith Richard S, Ayadi Hammadi, John Simon W M
Abstract excerpt
Angle-closure glaucoma (ACG) is a subset of glaucoma affecting 16 million people. Although 4 million people are bilaterally blind from ACG, the causative molecular mechanisms of ACG remain to be defined. High intraocular pressure induces glaucoma in ACG. High intraocular pressure traditionally was suggested to result from the iris blocking or closing the angle of the eye, thereby limiting aqueous humor drainage....
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