Article
Discovery of rare mutations in populations: TILLING by sequencing.
Plant physiology - 1 Jul 2011
Tsai Helen, Howell Tyson, Nitcher Rebecca, Missirian Victor, Watson Brian, Ngo Kathie J, Lieberman Meric, Fass Joseph, Uauy Cristobal, Tran Robert K, Khan Asif Ali, Filkov Vladimir, Tai Thomas H, Dubcovsky Jorge, Comai Luca
Abstract excerpt
Discovery of rare mutations in populations requires methods, such as TILLING (for Targeting Induced Local Lesions in Genomes), for processing and analyzing many individuals in parallel. Previous TILLING protocols employed enzymatic or physical discrimination of heteroduplexed from homoduplexed ta...
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