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Article

Cellular and Molecular Mechanisms of Apoptosis in Age-Related Muscle Atrophy

1 Jan 2012

Abstract excerpt

Age-related muscle atrophy is due to loss of muscle fibers as well as atrophy of the remaining fibers. Evidence shows that loss of myofibers may be, in part, due to apoptosis. Two major apoptotic pathways have been extensively studied which are the mitochondrion-mediated and receptor-mediated pathways. However, other pathways exist, such as the p53 pathway. To date, it is not completely clear what pathways are...

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PMID: 21529323
DOI: 10.2174/1874609811104030269

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