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Article

Prognostic significance of molecular markers and extent of resection in primary glioblastoma patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2009

Felsberg Jörg, Rapp Marion, Loeser Simon, Fimmers Rolf, Stummer Walter, Goeppert Matthias, Steiger Hans-Jacob, Friedensdorf Britta, Reifenberger Guido, Sabel Michael C

Abstract excerpt

PURPOSE: Despite multimodal aggressive treatment glioblastoma patients still face a rather poor prognosis. Recent data indicate that certain molecular markers, in particular MGMT promoter hypermethylation, are associated with response to alkylating chemotherapy and longer survival. The clinical significance of other glioblastoma-associated molecular aberrations and their relationship to MGMT promoter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19861461
DOI: 10.1158/1078-0432.CCR-08-2801

Genes

MGMT
CDK4
EGFR
MDM2
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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