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Article

Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease.

Annals of neurology - 1 Apr 2011

Chen-Plotkin Alice S, Hu William T, Siderowf Andrew, Weintraub Daniel, Goldmann Gross Rachel, Hurtig Howard I, Xie Sharon X, Arnold Steven E, Grossman Murray, Clark Christopher M, Shaw Leslie M, McCluskey Leo, Elman Lauren, Van Deerlin Vivianna M, Lee Virginia M-Y, Soares Holly, Trojanowski John Q

Abstract excerpt

OBJECTIVE: Most people with Parkinson disease (PD) eventually develop cognitive impairment (CI). However, neither the timing of onset nor the severity of cognitive symptoms can be accurately predicted. We sought plasma-based biomarkers for CI in PD. METHODS: A discovery cohort of 70 PD patients was recruited. Cognitive status was evaluated with the Mattis Dementia Rating Scale-2 (DRS) at baseline and on annual...

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Identifiers

PMID: 21520231
DOI: 10.1002/ana.22271
PMCID: PMC3155276

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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