The AVPR1A gene and substance use disorders: association, replication, and functional evidence.

doi:10.1016/j.biopsych.2011.02.023

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Article

The AVPR1A gene and substance use disorders: association, replication, and functional evidence.

Biological psychiatry - 15 Sept 2011

Maher Brion S, Vladimirov Vladimir I, Latendresse Shawn J, Thiselton Dawn L, McNamee Rebecca, Kang Moonsu, Bigdeli Tim B, Chen Xiangning, Riley Brien P, Hettema John M, Chilcoat Howard, Heidbreder Christian, Muglia Pierandrea, Murrelle E Lenn, Dick Danielle M, Aliev Fazil, Agrawal Arpana, Edenberg Howard J, Kramer John, Nurnberger John, Tischfield Jay A, Devlin Bernie, Ferrell Robert E, Kirillova Galina P, Tarter Ralph E, Kendler Kenneth S, Vanyukov Michael M

Abstract excerpt

BACKGROUND: The liability to addiction has been shown to be highly genetically correlated across drug classes, suggesting nondrug-specific mechanisms. METHODS: In 757 subjects, we performed association analysis between 1536 single nucleotide polymorphisms (SNPs) in 106 candidate genes and a drug use disorder diagnosis (DUD). RESULTS: Associations (p ≤ .0008) were detected with three SNPs in the arginine...

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Identifiers

PMID: 21514569
DOI: 10.1016/j.biopsych.2011.02.023
PMCID: PMC4083653

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