Nodulogenesis and goitrogenesis.

Abstract excerpt

Goitrogenisis is the consequence of a relative iodine deficiency interacting with a genetic predisposition for maladaptation to iodine deficiency. In the long run, the iodine deficiency induces increased H₂O₂ production that leads to an increased mutagenesis, resulting in somatic mutations with a proliferative advantage and thus the induction of thyroid nodules.

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