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Article

Pro-apoptotic activity of α-bisabolol in preclinical models of primary human acute leukemia cells.

Journal of translational medicine - 21 Apr 2011

Cavalieri Elisabetta, Rigo Antonella, Bonifacio Massimiliano, Carcereri de Prati Alessandra, Guardalben Emanuele, Bergamini Christian, Fato Romana, Pizzolo Giovanni, Suzuki Hisanori, Vinante Fabrizio

Abstract excerpt

BACKGROUND: We previously demonstrated that the plant-derived agent α-bisabolol enters cells via lipid rafts, binds to the pro-apoptotic Bcl-2 family protein BID, and may induce apoptosis. Here we studied the activity of α-bisabolol in acute leukemia cells. METHODS: We tested ex vivo blasts from 42 acute leukemias (14 Philadelphia-negative and 14 Philadelphia-positive B acute lymphoid leukemias, Ph-/Ph+B-ALL; 14...

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Identifiers

PMID: 21510902
DOI: 10.1186/1479-5876-9-45
PMCID: PMC3112094

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BID

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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