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Article

Pterostilbene downregulates BCR/ABL and induces apoptosis of T315I-mutated BCR/ABL-positive leukemic cells.

Scientific reports - 13 Jan 2022

Kawakami Shohei, Tsuma-Kaneko Mitsuyo, Sawanobori Masakazu, Uno Tomoko, Nakamura Yoshihiko, Matsuzawa Hideyuki, Suzuki Rikio, Onizuka Makoto, Yahata Takashi, Naka Kazuhito, Ando Kiyoshi, Kawada Hiroshi

Abstract excerpt

In this study, we examined the antileukemic effects of pterostilbene, a natural methylated polyphenol analog of resveratrol that is predominantly found in berries and nuts, using various human and murine leukemic cells, as well as bone marrow samples obtained from patients with leukemia. Pterostilbene administration significantly induced apoptosis of leukemic cells, but not of non-malignant hematopoietic...

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Identifiers

PMID: 35027628
DOI: 10.1038/s41598-021-04654-1
PMCID: PMC8758722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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