Article
Corticotrophin-releasing hormone type 1 receptor gene (CRHR1) variants predict posttraumatic stress disorder onset and course in pediatric injury patients.
Disease markers - 1 Jan 2011
Amstadter Ananda B, Nugent Nicole R, Yang Bao-Zhu, Miller Alisa, Siburian Richie, Moorjani Priya, Haddad Stephen, Basu Aditi, Fagerness Jesen, Saxe Glenn, Smoller Jordan W, Koenen Karestan C
Abstract excerpt
Posttraumatic stress disorder (PTSD) is a common and disabling anxiety disorder that may occur in the aftermath of exposure to potentially traumatic life events. PTSD is moderately heritable, but few specific molecular variants accounting for this heritability have been identified. Genes regulating the hypothalamic-pituitary-adrenal (HPA) axis, such as corticotrophin-releasing hormone type 1 receptor gene...
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