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Article

Oncosuppressor methylation: a possible key role in colon metastatic progression.

Journal of cellular physiology - 1 Jul 2011

Tommasi Stefania, Pinto Rosamaria, Petriella Daniela, Pilato Brunella, Lacalamita Rosanna, Santini Daniele, Zito Francesco, Colucci Giuseppe, Paradiso Angelo, Silvestris Nicola

Abstract excerpt

K-RAS and BRAF gene mutations are mandatory to set anti-EGFR therapy in metastatic colorectal cancer (mCRC) patients. Due to the relationship of these mutations with tumor epigenotype, we hypothesized the potential role of oncosuppressor methylation of genes involved in K-RAS/BRAF pathway (CDKN2A, RASSF1A, and RARbeta suppressor genes) in inhibiting EGFR signaling cascade. Primary tumor and synchronous liver...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21506124
DOI: 10.1002/jcp.22524

Genes

BRAF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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