Article
Zinc inhibition of bacterial cytochrome bc(1) reveals the role of cytochrome b E295 in proton release at the Q(o) site.
Biochemistry - 24 May 2011
Lee Dong-Woo, El Khoury Youssef, Francia Francesco, Zambelli Barbara, Ciurli Stefano, Venturoli Giovanni, Hellwig Petra, Daldal Fevzi
Abstract excerpt
The cytochrome (cyt) bc(1) complex (cyt bc(1)) plays a major role in the electrogenic extrusion of protons across the membrane responsible for the proton motive force to produce ATP. Proton-coupled electron transfer underlying the catalysis of cyt bc(1) is generally accepted, but the molecular basis of coupling and associated proton efflux pathway(s) remains unclear. Herein we studied Zn(2+)-induced inhibition of...
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