Article
Across membrane communication between the Q(o) and Q(i) active sites of cytochrome bc(1).
Biochemistry - 10 Mar 2009
Cooley Jason W, Lee Dong-Woo, Daldal Fevzi
Abstract excerpt
The ubihydroquinone:cytochrome c oxidoreductase (cyt bc(1)) contains two catalytically active domains, termed the hydroquinone oxidation (Q(o)) and quinone reduction (Q(i)) sites, which are distant from each other by over 30 A. Previously, we have reported that binding of inhibitors to the Q(i) site on one (n) side of the energy-transducing membrane changes the local environment of the iron-sulfur (Fe/S) protein...
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