Article
Distinct roles of transforming growth factor-beta-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9.
The Journal of biological chemistry - 17 Jun 2011
Refaat Alaa, Zhou Yue, Suzuki Shunsuke, Takasaki Ichiro, Koizumi Keiichi, Yamaoka Shoji, Tabuchi Yoshiaki, Saiki Ikuo, Sakurai Hiroaki
Abstract excerpt
Investigation of helper T cell markers in HTLV-1-transformed cell lines demonstrated that HuT-102 has an IL-9-producing Th17 phenotype. We confirmed the vital role of retinoic acid-related orphan receptor C, a Th17 transcription factor, in the expression of IL-17. Interferon regulatory factor 4 (...
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