Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6

14 Sept 2009

Abstract excerpt

Nephronophthisis (NPH) is an autosomal recessive disorder characterized by renal fibrosis, tubular basement membrane disruption and corticomedullary cyst formation leading to end-stage renal failure. The disease is caused by mutations in NPHP1-9 genes, which encode the nephrocystins, proteins localized to cell-cell junctions and centrosome/primary cilia. Here, we show that nephrocystin mRNA expression is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Kidney Cyst Diseases
Share to Organ Donation and Transplantation
Share to Renal and related cancers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19755384
DOI: 10.1093/hmg/ddp434

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6PMID 19755384Read ↗

Nephronophthisis.Semantic proximity Read ↗

Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes.Semantic proximity Read ↗

Nephrocystin Specifically Localizes to the Transition Zone of Renal and Respiratory Cilia and Photoreceptor Connecting CiliaSemantic proximity Read ↗

Nephronophthisis.Semantic proximity Read ↗

Nephrocystin-4 is required for pronephric duct-dependent cloaca formation in zebrafish.Semantic proximity Read ↗

The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure.Semantic proximity Read ↗

Targeted disruption of Nphp1 causes male infertility due to defects in the later steps of sperm morphogenesis in mice.Semantic proximity Read ↗

Urinary renal epithelial cells can be used for NPHP1 phenotyping and a personalized therapeutic strategy.Semantic proximity Read ↗

Nephronophthisis-Associated CiliopathiesSemantic proximity Read ↗

Loss of nephronophthisis-associated nephrocystin-1 impairs DNA damage repair in kidney organoidsSemantic proximity Read ↗

NephronophthisisSemantic proximity Read ↗

Molecular Genetics of Nephronophthisis and Medullary Cystic Kidney DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.