Article
SNAP-25 single nucleotide polymorphisms are associated with hyperactivity in autism spectrum disorders.
Pharmacological research - 1 Sept 2011
Guerini Franca R, Bolognesi Elisabetta, Chiappedi Matteo, Manca Salvatorica, Ghezzo Alessandro, Agliardi Cristina, Sotgiu Stefano, Usai Sonia, Matteoli Michela, Clerici Mario
Abstract excerpt
Synaptosomal-associated protein of 25kD (SNAP-25), a protein participating in the regulation of synaptic vesicle exocytosis and in calcium homeostasis, was recently involved in neuropsychiatric conditions. Because alterations affecting the homeostasis of calcium are described in patients affected by autism spectrum disorders (ASD) we investigated a possible involvement of SNAP-25 in ASD by evaluating five SNAP-25...
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