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Article

Heme oxygenase-1 germ line GTn promoter polymorphism is an independent prognosticator of tumor recurrence and survival in pancreatic cancer.

Journal of surgical oncology - 1 Sept 2011

Vashist Yogesh K, Uzungolu Guentac, Kutup Asad, Gebauer Florian, Koenig Alexandra, Deutsch Lena, Zehler Oliver, Busch Philipp, Kalinin Viacheslav, Izbicki Jakob R, Yekebas Emre F

Abstract excerpt

BACKGROUND: Heme oxygenase-1 (HO-1) correlates with aggressive tumor behavior and chemotherapy resistance in pancreatic cancer (PC). We evaluated the prognostic value of the basal transcription controlling germ line GTn repeat polymorphism (GTn) in the promoter region of the HO-1 gene in PC. PATIENTS AND METHODS: We determined the GTn in 100 controls and 150 PC patients. DNA was extracted from blood leukocytes...

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PMID: 21495030
DOI: 10.1002/jso.21926

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