Article
Are toxicological responses in laboratory (inbred) zebrafish representative of those in outbred (wild) populations? - A case study with an endocrine disrupting chemical.
Environmental science & technology - 1 May 2011
Brown A Ross, Bickley Lisa K, Le Page Gareth, Hosken David John, Paull Gregory C, Hamilton Patrick B, Owen Stewart F, Robinson Joanna, Sharpe Alan D, Tyler Charles R
Abstract excerpt
Laboratory animals tend to be more inbred and less genetically diverse than wild populations, and thus may differ in their susceptibility to chemical stressors. We tested this hypothesis by comparing the responses of related inbred (theoretical inbreeding F(IT) = n + 0.25) and outbred (F(IT) = n) zebrafish (Danio rerio) WIK/Wild family lines to an endocrine disrupting chemical, clotrimazole. Exposure of inbred...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.