Article
Genomic signatures of strain selection and enhancement in Bacillus atrophaeus var. globigii, a historical biowarfare simulant.
PloS one - 25 Mar 2011
Gibbons Henry S, Broomall Stacey M, McNew Lauren A, Daligault Hajnalka, Chapman Carol, Bruce David, Karavis Mark, Krepps Michael, McGregor Paul A, Hong Charles, Park Kyong H, Akmal Arya, Feldman Andrew, Lin Jeffrey S, Chang Wenling E, Higgs Brandon W, Demirev Plamen, Lindquist John, Liem Alvin, Fochler Ed, Read Timothy D, Tapia Roxanne, Johnson Shannon, Bishop-Lilly Kimberly A, Detter Chris, Han Cliff, Sozhamannan Shanmuga, Rosenzweig C Nicole, Skowronski Evan W
Abstract excerpt
BACKGROUND: Despite the decades-long use of Bacillus atrophaeus var. globigii (BG) as a simulant for biological warfare (BW) agents, knowledge of its genome composition is limited. Furthermore, the ability to differentiate signatures of deliberate adaptation and selection from natural variation is lacking for most bacterial agents. We characterized a lineage of BGwith a long history of use as a simulant for BW...
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