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Effects of histocompatibility and host immune responses on the tumorigenicity of pluripotent stem cells

3 Apr 2011

Abstract excerpt

Pluripotent stem cells hold great promises for regenerative medicine. They might become useful as a universal source for a battery of new cell replacement therapies. Among the major concerns for the clinical application of stem cell-derived grafts are the risks of immune rejection and tumor formation. Pluripotency and tumorigenicity are closely linked features of pluripotent stem cells. However, the capacity to...

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PMID: 21461989
DOI: 10.1007/s00281-011-0266-8

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