Article
Evaluation of a fibrillin 2 gene haplotype associated with hip dysplasia and incipient osteoarthritis in dogs.
American journal of veterinary research - 1 Apr 2011
Friedenberg Steven G, Zhu Lan, Zhang Zhiwu, Foels Wendy van den Berg, Schweitzer Peter A, Wang Wei, Fisher Patricia J, Dykes Nathan L, Corey Elizabeth, Vernier-Singer Margaret, Jung Seung-Woo, Sheng Xihui, Hunter Linda S, McDonough Sean P, Lust George, Bliss Stuart P, Krotscheck Ursula, Gunn Teresa M, Todhunter Rory J
Abstract excerpt
OBJECTIVE: To determine whether a mutation in the fibrillin 2 gene (FBN2) is associated with canine hip dysplasia (CHD) and osteoarthritis in dogs. ANIMALS: 1,551 dogs. Procedures-Hip conformation was measured radiographically. The FBN2 was sequenced from genomic DNA of 21 Labrador Retrievers and 2 Greyhounds, and a haplotype in intron 30 of FBN2 was sequenced in 90 additional Labrador Retrievers and 143 dogs of...
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