Article
Differential genetic regulation of canine hip dysplasia and osteoarthritis.
PloS one - 11 Oct 2010
Zhou Zhengkui, Sheng Xihui, Zhang Zhiwu, Zhao Keyan, Zhu Lan, Guo Gang, Friedenberg Steve G, Hunter Linda S, Vandenberg-Foels Wendy S, Hornbuckle William E, Krotscheck Ursula, Corey Elizabeth, Moise Nancy S, Dykes Nathan L, Li Junya, Xu Shangzhong, Du Lixin, Wang Yachun, Sandler Jody, Acland Gregory M, Lust George, Todhunter Rory J
Abstract excerpt
BACKGROUND: Canine hip dysplasia (HD) is a common polygenic trait characterized by hip malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human hip which also leads to OA. METHODOLOGY/PRINCIPAL FINDINGS: A total of 721 dogs, including both an association and linkage population, were genotyped. The association population included 8 pure breeds...
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