Article
Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice.
Chronobiology international - 1 Apr 2011
Durgan David J, Tsai Ju-Yun, Grenett Maximiliano H, Pat Betty M, Ratcliffe William F, Villegas-Montoya Carolina, Garvey Merissa E, Nagendran Jeevan, Dyck Jason R B, Bray Molly S, Gamble Karen L, Gimble Jeffrey M, Young Martin E
Abstract excerpt
Circadian dyssynchrony of an organism (at the whole-body level) with its environment, either through light-dark (LD) cycle or genetic manipulation of clock genes, augments various cardiometabolic diseases. The cardiomyocyte circadian clock has recently been shown to influence multiple myocardial processes, ranging from transcriptional regulation and energy metabolism to contractile function. The authors,...
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