Article
Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients.
Science translational medicine - 30 Mar 2011
Jons Christian, O-Uchi Jin, Moss Arthur J, Reumann Matthias, Rice John J, Goldenberg Ilan, Zareba Wojciech, Wilde Arthur A M, Shimizu Wataru, Kanters Jorgen K, McNitt Scott, Hofman Nynke, Robinson Jennifer L, Lopes Coeli M B
Abstract excerpt
Inherited long QT syndrome (LQTS) is caused by mutations in ion channels that delay cardiac repolarization, increasing the risk of sudden death from ventricular arrhythmias. Currently, the risk of sudden death in individuals with LQTS is estimated from clinical parameters such as age, gender, and the QT interval, measured from the electrocardiogram. Even though a number of different mutations can cause LQTS,...
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