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Article

Treatment with the antiepileptic drugs phenytoin and gabapentin ameliorates seizure and paralysis of Drosophila bang-sensitive mutants.

Journal of neurobiology - 1 Mar 2004

Reynolds Elaine R, Stauffer Eric A, Feeney Laura, Rojahn Elizabeth, Jacobs Benjamin, McKeever Carol

Abstract excerpt

Drosophila bang-sensitive (bs) mutants exhibit a stereotypic seizure and paralysis following exposure to mechanical shock. In a physiological preparation, seizures and failures corresponding to the defective behavior are observed in response to high frequency stimulation. The amplitude of the stimulus necessary to produce bs behavior, or seizure threshold, varies with bs mutant and its gene dosage. In many...

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PMID: 14978727
DOI: 10.1002/neu.10297

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