Article
Tachykinin receptor 1 variants associated with aggression in suicidal behavior.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2007
Giegling Ina, Rujescu Dan, Mandelli Laura, Schneider Barbara, Hartmann Annette M, Schnabel Axel, Maurer Konrad, De Ronchi Diana, Möller Hans-Jürgen, Serretti Alessandro
Abstract excerpt
Substance P is involved in the modulation of depression, anxiety, and suicidal-related behaviors. We studied gene variants of Tachykinin Receptor 1 (TACR1-rs3771810, rs3771825, rs726506, rs1477157) in 167 German suicide attempters (affective spectrum n = 107, schizophrenia spectrum n = 35, borderline personality disorder n = 25), 92 Caucasian individuals who committed suicide and 312 German healthy subjects....
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