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Titanium Salan Complexes Displays Strong Antitumor Properties In Vitro and In Vivo in Mice

21 Mar 2011

Abstract excerpt

The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan...

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PMID: 21445304
DOI: 10.1371/journal.pone.0017869

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