Article
Glucocorticoid receptor haplotype is associated with a decreased risk of delirium in the elderly.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2011
Manenschijn L, van Rossum E F C, Jetten A M, de Rooij S E, van Munster B C
Abstract excerpt
Delirium is the most common mental disorder at older age in hospitals after acute admission. The pathogenesis of delirium is largely unknown. Hyperactivity of the hypothalamic-pituitary-adrenal axis, leading to increased cortisol levels, has been suggested to play a role in the development of delirium. The effects of cortisol, the most important glucocorticoid (GC) in humans, are mainly mediated by the GC...
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