Article
Transforming growth factor-β, a whey protein component, strengthens the intestinal barrier by upregulating claudin-4 in HT-29/B6 cells.
The Journal of nutrition - 1 May 2011
Hering Nina A, Andres Susanne, Fromm Anja, van Tol Eric A, Amasheh Maren, Mankertz Joachim, Fromm Michael, Schulzke Joerg D
Abstract excerpt
TGFβ (isoforms 1-3) has barrier-protective effects in the intestine. The mechanisms involved in regulating tight junction protein expression are poorly understood. The aim of this study was to elucidate TGFβ-dependent protective effects with special attention to promoter regulation of tight junction proteins using the HT-29/B6 cell model. In addition, the effects of whey protein concentrate 1 (WPC1), a natural...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.