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Article

ZEB1 is estrogen responsive in vitro in human foreskin cells and is over expressed in penile skin in patients with severe hypospadias.

The Journal of urology - 1 May 2011

Qiao Liang, Tasian Gregory E, Zhang Haiyang, Cunha Gerald R, Baskin Laurence

Abstract excerpt

PURPOSE: We determined the effect of estrogen on ZEB1 in vitro and tested the hypothesis that ZEB1 is over expressed in the penile skin of subjects with hypospadias. MATERIALS AND METHODS: Hs68 cells, a fibroblast cell line derived from human foreskin, were exposed to 0, 1, 10 and 100 nM estrogen, and the expression level of ZEB1 was assessed using reverse transcription real-time polymerase chain reaction,...

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Source

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Identifiers

PMID: 21421232
DOI: 10.1016/j.juro.2010.12.066
PMCID: PMC3428058

Genes

ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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