Article
A polymorphism of the ORAI1 gene is associated with the risk and recurrence of calcium nephrolithiasis.
The Journal of urology - 1 May 2011
Chou Yii-Her, Juo Suh-Hang Hank, Chiu Yi-Ching, Liu Mu-En, Chen Wei-Chiao, Chang Chen-Chia, Chang Wei-Pin, Chang Jan-Gowth, Chang Wei-Chiao
Abstract excerpt
PURPOSE: Store-operated calcium entry has been considered an important factor to regulate inflammatory reactions in nonexcitable cells. However, the effects of genetic polymorphisms of ORAI1, a main component of store-operated calcium channels, on nephrolithiasis and stone recurrence remain unclear. We investigated the association between calcium containing nephrolithiasis and genetic variants of ORAI1 gene in...
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