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Article

Study of the association between ITPKC genetic polymorphisms and calcium nephrolithiasis.

BioMed research international - 1 Jan 2014

Kan Wei-Chih, Chou Yii-Her, Chiu Siou-Jin, Hsu Yu-Wen, Lu Hsing-Fang, Hsu Wenli, Chang Wei-Chiao

Abstract excerpt

Nephrolithiasis is a multifactorial disease caused by environmental, hormonal, and genetic factors. Genetic polymorphisms of ORAI1, which codes for the main subunit of the store-operated calcium (SOC) channel, were reported to be associated with the risk and recurrence of calcium nephrolithiasis. Inositol 1,4,5-trisphosphate (IP3) 3-kinase C (ITPKC) is a negative regulator of the SOC channel-mediated signaling...

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Source

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Identifiers

PMID: 24800221
DOI: 10.1155/2014/397826
PMCID: PMC3988947

Genes

ITPKC
ORAI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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