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Article

Second-order selection for evolvability in a large Escherichia coli population.

Science (New York, N.Y.) - 18 Mar 2011

Woods Robert J, Barrick Jeffrey E, Cooper Tim F, Shrestha Utpala, Kauth Mark R, Lenski Richard E

Abstract excerpt

In theory, competition between asexual lineages can lead to second-order selection for greater evolutionary potential. To test this hypothesis, we revived a frozen population of Escherichia coli from a long-term evolution experiment and compared the fitness and ultimate fates of four genetically distinct clones. Surprisingly, two clones with beneficial mutations that would eventually take over the population had...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21415350
DOI: 10.1126/science.1198914
PMCID: PMC3176658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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